ACIU — AC Immune SA

Frequently asked questions about ACIU

How does DeepScreen analyze AC Immune SA?

DeepScreen uses a 13-factor valuation and quality model. The methodology explains the inputs, weighting and limitations; model output is analytical research, not a personalized investment recommendation.

What is ACIU's P/E ratio?

A provider-backed P/E is currently unavailable. The defensible approach is to calculate or verify it from the latest price and reported trailing earnings rather than substitute a synthetic figure.

How should I assess AC Immune SA's profitability?

For AC Immune SA, the latest provider-backed snapshot shows the latest growth measure is 1057.20%, net margin is -246.48%, ROE is -78.5%. Consistent profitability and healthy year-over-year growth should be confirmed over several reporting periods, with earnings reconciled to operating cash flow and one-off items removed from the analysis.

How much debt does AC Immune SA have?

The latest provider-backed debt-to-equity ratio is 0.12x. Total debt is approximately $4.10M, while cash is approximately $75.36M. Assess leverage together with interest expense, maturities and operating cash flow.

Is ACIU a buy?

DeepScreen provides research tools rather than a personalized recommendation. A decision should consider business quality, valuation, balance-sheet risk, disclosures, liquidity and your own objectives and risk tolerance.

How does the company make money?

AC Immune SA, a clinical stage biopharmaceutical company, discovers, designs, and develops medicines, and therapeutic and diagnostic products for the prevention and treatment of neurodegenerative diseases associated with protein misfolding. The company's SupraAntigen and Morphomer platforms are designed to generate biologics and small molecules, which selectively interact with misfolded proteins that are common in a range of neurodegenerative diseases. It develops Crenezumab, a humanized, conformation specific monoclonal antibody used to slow Alzheimer's disease (AD) progression; and Semorinemab, an investigational monoclonal anti-Tau antibody that targets the N-terminal portion of the Tau protein and is designed to bind to Tau and slow its spread between neurons for the treatment of AD. The company is also developing ACI-24.060 for the treatment of down syndrome related AD; ACI-7104.056 to treat Parkinson's disease; and ACI-35.030, designs to stimulate a patient's immune system to produce antibodies against pathological phosphorylated Tau. In addition, it develops diagnostic programs consisting of PI-2620, a Tau diagnostic for AD, as well as non-AD Tauopathies; and ACI-12589 and ACI-15916, a-sync PET tracer that supports the differential diagnosis of multiple system atrophy from other neurodegenerative diseases. Further, the company is researching and developing Morphomer Tau aggregation inhibitors to evaluate candidates in AD; Morphomer a-syn to compete with small molecule inhibitors of a-syn aggregation; and NeuroOrphan Tauopathies. Additionally, it generates discovery and preclinical stage molecules targeting range of neurodegenerative diseases, which include diagnostics targeting TDP-43, alpha-synuclein, and NLRP3. The company has license agreements and collaborations with Genentech, Inc.; Janssen Pharmaceuticals, Inc.; Life Molecular Imaging SA; and Eli Lilly and Company. AC Immune SA was incorporated in 2003 and is headquartered in Lausanne, Switzerland. This describes the company's disclosed business activity; for exact segment revenue, geography and customer concentration, use the latest annual report.

What is the company's competitive advantage (economic moat)?

AC Immune SA's potential moat should be evaluated from observable business economics: scale or cost advantages, network effects, switching costs, brand strength, patents or licences, distribution advantages and barriers to entry. The strongest evidence is a durable combination of pricing power, stable/growing margins and returns on capital over many years; a high ROE or ROCE alone does not prove a moat.

Who are the main competitors, and how does the company differ from them?

DeepScreen's directory-based comparison candidates include MRP (Millrose Properties, Inc. Class A), PDM (Piedmont Realty Trust, Inc. Class A), VERU (Veru Inc.), UROY (Uranium Royalty Corp.), CAC (Camden National Corporation). Sector labels and market-cap proximity can use inferred or modeled directory inputs; these candidates are not a verified list of direct competitors; the direct comparison should use products, customers, geography, margins, growth, returns on capital and valuation.

Are its products or services in long-term demand?

The provider classifies AC Immune SA in Biotechnology. Long-term demand is supported when the underlying industry, customer base and product/service use remain durable over multiple years. For AC Immune SA, test that through multi-year revenue and customer trends, retention/repeat purchases where applicable, pricing power, capacity utilisation and the risk of substitution or technological disruption.

Who are its primary customers (individuals, businesses, or government)?

The provider's business profile describes AC Immune SA's activities as follows: AC Immune SA, a clinical stage biopharmaceutical company, discovers, designs, and develops medicines, and therapeutic and diagnostic products for the prevention and treatment of neurodegenerative diseases associated with protein misfolding. The company's SupraAntigen and Morphomer platforms are designed to generate biologics and small molecules, which selectively interact with misfolded proteins that are common in a range of neurodegenerative diseases. It develops Crenezumab, a humanized, conformation specific monoclonal antibody used to slow Alzheimer's disease (AD) progression; and Semorinemab, an investigational monoclonal anti-Tau antibody that targets the N-terminal portion of the Tau protein and is designed to bind to Tau and slow its spread between neurons for the treatment of AD. The company is also developing ACI-24.060 for the treatment of down syndrome related AD; ACI-7104.056 to treat Parkinson's disease; and ACI-35.030, designs to stimulate a patient's immune system to produce antibodies against pathological phosphorylated Tau. In addition, it develops diagnostic programs consisting of PI-2620, a Tau diagnostic for AD, as well as non-AD Tauopathies; and ACI-12589 and ACI-15916, a-sync PET tracer that supports the differential diagnosis of multiple system atrophy from other neurodegenerative diseases. Further, the company is researching and developing Morphomer Tau aggregation inhibitors to evaluate candidates in AD; Morphomer a-syn to compete with small molecule inhibitors of a-syn aggregation; and NeuroOrphan Tauopathies. Additionally, it generates discovery and preclinical stage molecules targeting range of neurodegenerative diseases, which include diagnostics targeting TDP-43, alpha-synuclein, and NLRP3. The company has license agreements and collaborations with Genentech, Inc.; Janssen Pharmaceuticals, Inc.; Life Molecular Imaging SA; and Eli Lilly and Company. AC Immune SA was incorporated in 2003 and is headquartered in Lausanne, Switzerland. Customer mix itself is not a stock-market ratio, so the primary customers should be confirmed from the company's segment, geographic and customer disclosures.

Is the company consistently profitable, and is its revenue growing year-over-year?

For AC Immune SA, the latest provider-backed snapshot shows the latest growth measure is 1057.20%, net margin is -246.48%, ROE is -78.5%. Consistent profitability and healthy year-over-year growth should be confirmed over several reporting periods, with earnings reconciled to operating cash flow and one-off items removed from the analysis.

Does the company generate positive, healthy free cash flow?

The latest provider snapshot reports free cash flow of approximately $-33.14M, with operating cash flow of about $-50.49M. Whether that cash flow is healthy depends on persistence, conversion of profit to cash, capital expenditure needs and working-capital movements; inspect multiple periods rather than one TTM figure.

How high are the company's debt levels compared to its cash holdings and earnings?

The current snapshot shows D/E of 0.12x, debt of roughly $4.10M, cash of roughly $75.36M, implying net debt of about $-71.25M. The full debt burden should be compared with EBITDA/EBIT, interest expense, maturities and recurring free cash flow.

How will the company finance its future growth or expansion projects?

AC Immune SA currently has reported cash of about $75.36M and free cash flow of about $-33.14M. Those internal resources can contribute to expansion, while additional funding can come from operating cash flow, debt, equity issuance, asset sales or project finance. The exact funding mix for a specific project must come from management's disclosed plans.

What is the company's historical Return on Equity (ROE) and Return on Capital Employed (ROCE)?

The latest snapshot reports ROE of -78.5%no current live ROCE. Historical quality should be judged from a multi-year series and by checking whether returns remain above the company's cost of capital through different business conditions.

Who are the promoters or top executives running the company, and what is their track record?

The current provider profile lists these senior executives: Mr. Christopher Roberts (CFO & VP of Finance); Mr. Piergiorgio Donati (Chief Operating Officer); Dr. Martin Zugel M.D., Ph.D. (Interim CEO & Chairman of the Board); Dr. Gary Anthony Waanders Ph.D. (Senior VP of Investor Relations & Corporate Communications); Dr. Matthias Maurer Ph.D. (Senior VP & General Counsel). Track record should be assessed through capital-allocation decisions, operating results, governance disclosures and execution against stated targets. For Indian companies, promoter identity and ownership should be checked against the latest exchange shareholding filing.

Is a high percentage of the promoter's stake pledged as collateral for loans?

Promoter pledge is a shareholding-disclosure item, not a normal valuation ratio. For an Indian company, check the latest exchange shareholding pattern and notes for pledged/encumbered promoter shares, and compare the percentage with prior quarters to identify changes. Do not infer pledge levels from debt-to-equity.

Does management have a transparent and honest history of communication with shareholders?

The strongest evidence is consistency between what management says and what later appears in reported results: guidance versus delivery, explanations for misses, treatment of related parties, restatements, capital allocation and disclosure of material risks. A multi-year record is needed; tone alone is not a reliable measure of transparency.

Has the firm ever faced corporate governance issues, legal troubles, or accounting scandals?

This question requires a dated event history. Review regulator orders, exchange notices, audited-report qualifications, court records and reputable reporting, and distinguish allegations or investigations from settlements and established findings. The absence of a warning label on a stock page is not proof that no historical event ever occurred.

Is the current stock valuation (such as the P/E or P/S ratio) reasonable or overpriced?

A live provider-backed P/E is not available and P/S is 15.02x . These are descriptive multiples, not conclusions by themselves. A defensible valuation assessment compares the multiple with sustainable growth, margins, ROE/ROCE, balance-sheet risk, cyclicality and direct peers.

How does the company's valuation compare to its direct industry peers?

A practical peer set for AC Immune SA starts with MRP (Millrose Properties, Inc. Class A), PDM (Piedmont Realty Trust, Inc. Class A), VERU (Veru Inc.), UROY (Uranium Royalty Corp.), CAC (Camden National Corporation). Compare the same reporting-period P/E, P/S and positive EV/EBITDA only when EBITDA supports a meaningful multiple, then adjust for growth, margin quality, leverage and business mix; a lower positive multiple is not automatically cheaper on an economic-value basis.

What is the margin of safety if market conditions or the economy worsens?

Margin of safety is created by buying with a gap between conservative intrinsic value and market price, then stress-testing the downside case. The relevant stress tests are lower revenue/earnings growth, lower margins, higher funding costs, weaker working capital and a lower terminal valuation. There is no universal fixed percentage that applies to every company.

Does the company pay a reliable dividend, or does it aggressively buy back its own shares?

The current provider-backed dividend yield is not available and payout ratio is 0.00% . Dividend reliability should be checked across several years and against free cash flow, while buyback intensity should be verified from share-count changes, treasury-share activity and cash-flow statements. A one-year yield cannot establish a durable shareholder-distribution policy.